Factors Influencing the Occurrence of Multidrug-Resistant Tuberculosis (MDR-TB) in the Working Area of Langara Health Center, Konawe Kepulauan Regency
Keywords:
Contact History, Drug Side Effects, Knowledge, MDR-TB, Medication Regularity, Patient Motivation.Abstract
Multidrug-Resistant Tuberculosis (MDR-TB) represents one of the most critical challenges in global tuberculosis prevention and control. MDR-TB occurs when Mycobacterium tuberculosis develops resistance to at least isoniazid and rifampicin, the two most potent first-line anti-tuberculosis drugs. This study aimed to identify the factors influencing the occurrence of MDR-TB in the working area of Langara Health Center, Konawe Kepulauan Regency in 2023. A quantitative descriptive study with a cross-sectional design was employed. The total sampling technique was applied, involving all 47 registered TB patients in the working area of Langara Health Center during 2023. Data were collected through medical records and validated questionnaires, and analyzed using univariate and bivariate analysis (T-test and F-test) with a significance level of p < 0.05. Results showed that medication regularity (t = 11.246; p = 0.003), drug side effects (t = 6.128; p = 0.012), contact history with TB patients (t = 7.450; p = 0.006), patient motivation (t = 6.557; p = 0.011), and knowledge (t = 5.421; p = 0.016) each significantly influenced MDR-TB occurrence. Simultaneously, all five variables significantly influenced MDR-TB occurrence (F = 5.150; p = 0.003). Healthcare workers should intensify health promotion activities to strengthen medication adherence, manage drug side effects, and improve patient motivation and knowledge regarding MDR-TB prevention.
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